ENHANCE GLUTATHIONE


For people with neuroborreliosis, neurological symptoms resulting from a Bb infection, glutathione is perhaps the most important therapeutic substance. As important, it will limit the damage to the nervous system that can occur in the person with CLD.

Glutathione, GHS, is a potent free radical scavenger, helps to maintain red blood cell membrane integrity, can neutralize toxins (especially in the liver where it is found in high concentrations) and aids in the repair and synthesis of DNA. Its ability to neutralize toxins is particularly import to the person with LD as it can render inactive the neurotoxins produced by Bb. This affect of GHS can decrease the neurological symptoms as well as protect the nervous system from damage.

I, and other doctors treating CLD patients, have seen improvement in cognitive function within minutes of administering a GHS IV. The best way for you to increase your GHS levels is to take some orally, recent research shows that it is absorbed if taken in the reduced form even though the percentage of absorption is small, and to take the substances that either lead to the synthesis of it or help protect it and recycle it. These substances are in this formula.

FORMULA INGREDIENTS
amount per capsule

. l-glutathione reduced 35mg
.  RS alpha lipoic acid 100mg
.  Vitamin C 150mg
.  Selenium
(l-selenomethionine)
33mg
.  Magnesium Glycinate 15mg
.  Vitamin B6
(pyridoxal 5 phosphate)
5mg
.  N-Acetyl l-cysteine 250mg
.  Vitamin E
(mixed Tocopherols)
75mg
.  Melatonin 1mg


Glutathione and alpha lipoic acid have been discussed.

SELENIUM Glutathione peroxidase, an enzyme that destroys peroxide molecules (a toxic substance naturally found in our cells) is dependant on selenium for its formation. Selenium also helps regenerate GHS.

AJP - Heart and Circulatory Physiology, Vol 240, Issue 5 800-H803, Copyright © 1981 by American Physiological Society
Glutathione peroxidase, selenium, and prostaglandin synthesis in plateletsM. G. Doni, G. L. Avventi, L. Bonadiman and G. Bonaccorso

VITAMIN C AND NAC The following excerpt from the Canadian Asthma Prevention Institute shows the role of vitamin C and NAC in elevating GHS levels in tissues.

Glutathione (GSH) levels in blood plasma have been shown to be increased through supplementation with vitamin C and glutathione precursor, N-acetylcysteine (NAC).

Researchers, studying a 45-month-old girl with an inherited glutathione synthesis deficiency, observed that dosages of vitamin C of 3000mg/day increased white blood cell GSH fourfold and plasma GSH levels eightfold.

NAC supplementation at 800mg/day also increased white blood cell GSH by 350% and plasma levels by 200-500%.

Based on the improvements seen over a two week period, researchers decided to administer 3000mg of vitamin C for a period of one year.

Glutathione levels remained elevated, the hematocrit increased form a baseline of 25.4% to 32.6%, and the number of immature red blood cells decreased from 11% to 4%.

These results indicate that vitamin C can decrease cellular damage in patients with hereditary glutathione deficiency.71

The results of the efficacy of vitamin C in improving GSH levels in this study were supported by a previous double-blind study by CJ Johnson, et al..

They reported that by supplementing vitamin C at a rate of 500mg per day, in healthy individuals, the average blood cell glutathione concentration increased nearly 50%. A further 5% increase was achieved by increasing vitamin C to 2000mg/day.

MAGNESIUM is necessary for the synthesis of GHS.

Glutathione biosynthesis in human erythrocytes
I. Identification of the enzymes of glutathione synthesis in hemolysates Virginia Minnich, M. B. Smith, M. J. Brauner, and Philip W. Majerus

MELATONIN is an important hormone in the regulation of our immune system and has been shown to increase GHS peroxidase activity in our brains.

Melatonin stimulates brain glutathione peroxidase activity

L. R. Barlow-Walden, R. J. Reiter, M. Abe, M. Pablos, A. Menendez-Pelaez, L. -D. Chen and B. Poeggeler Department of Cellular and Structural Biology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284-7762, U.S.A. Received 19 September 1994; accepted 7 November 1994. Available online 27 January 2000.